Assistant Laboratory Animal Technician (ALAT) Practice Exam

Which species is known to be fatal to penicillin?

1. Rats

2. Guinea pigs

3. Hamsters

4. Mice

The correct answer is: Guinea pigs

Guinea pigs are particularly sensitive to penicillin because they lack certain enzymes that are necessary to break down this antibiotic. When guinea pigs are exposed to penicillin, it can disrupt their gut flora and lead to serious gastrointestinal complications, which can ultimately be fatal. This reaction is due to their unique gastrointestinal physiology that makes them more susceptible to the harmful effects of antibiotics that are otherwise safe for many other species. Understanding the sensitivities of different species to medications is a critical aspect of veterinary care and laboratory animal management, as it helps prevent adverse effects and ensures the well-being of the animals employed in research and testing.